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safescimet course 4.3 - Predictive Cell Culture Systems

Cell culture systems are integral parts of standard in vitro test methods in research and development of new drugs covering the major toxicology pathways for preclinical safety evaluation to generate robust data in screening assays on a sound cost effect relationship. This course introduces the principles of cell culture systems as a tool to monitor homeostasis and early onset of functional imbalance leading to toxicity as well as their use and impact for drug development. Upon completing the course students will be able to evaluate the strengths and the limits of specific cell culture systems and to discriminate between biochemical and cellular assays, in vitro and in vivo tests for safety purposes. Recent developments and new biomarker and their ability to improve predictability regarding species differences and extrapolation to human will be discussed.

Key questions addressed by the course

  • Limits and strengths of permanent versus primary cells
  • Test batteries for cytotoxicity and cellular dysfunction
  • Robust parameters to monitor cell functions
  • Use of ‘omics technologies to identify critical pathways of toxicity
  • Requirements on cell culture systems for screening / high throughput techniques
  • Alternative methods and regulatory requirements
Location 
Halle, Germany

On-site course dates

16 July 2018 to 19 July 2018
Course leader 
Prof Dr Daniel Dietrich
Prof Dr Heidi Foth
Couse certificate 
CPD, ECTS, MSc optional
Course fees 
  • Company - 2.500 EUR
  • Small and medium companies (up to 250 employees) - 1.250 EUR
  • Regulatory authorities (government) - 1.250 EUR
  • Academic institutions (universities) - 500 EUR