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safescimet course 4.4 - Pathology Interpretation in Drug Development

The aim of this course is to introduce the principles of pathology, including the preparation, examination and interpretation of tissues from toxicity studies. In addition, the relevance of pathology findings in animal studies to clinical risk assessment will be addressed by consideration of pathological processes and common target organs, including the liver and cardiovascular system. Pathology forms an important part of the data used to characterize the hazard of new drugs in research and development. All those individuals involved in designing preclinical safety studies or in interpreting or using data from these studies, will benefit from a deeper understanding of pathology. The course is carefully designed to be of value to those with little pathology knowledge and also to those already working in this area. The course aims to provide attendees with the knowledge they need to integrate pathology data into risk assessments. In addition, many of the current hot topics in toxicological pathology will be included in the course.

Key questions addressed by the course

  • Pathological processes and causes of cell injury. General pathology including acute and chronic inflammation
  • Pathology of organ systems including the immune, cardiovascular, CNS, kidney, liver and respiratory system
  • Disorders of tissue growth including neoplasia
  • Introduction to toxicological pathology
  • Integration of anatomic and clinical pathology
  • Distinguishing spontaneous from test article-related lesions in toxicity studies
  • Determining adverse versus non-adverse findings
  • Interpretation and reporting of pathology, including data from carcinogenicity studies Extrapolation of animal data to human risk assessment
  • Specialised techniques used in histology and electron microscopy including image analysis
Surrey, England

On-site course dates

18 June 2018 to 22 June 2018
Course leader 
Prof Shirley Price
Dr Philippe Detilleux
Couse certificate 
CPD, ECTS, MSc optional
Course fees 
  • Company - 2.500 EUR
  • Small and medium companies (up to 250 employees) - 1.250 EUR
  • Regulatory authorities (government) - 1.250 EUR
  • Academic institutions (universities) - 500 EUR